Scientific publications
CD137 (4-1BB) and T-Lymphocyte Exhaustion. Scientific Publication
Sep 13, 2024
| Magazine: Clinical Cancer Research
Paula Molero-Glez 1 , Arantza Azpilikueta 1 , Laura Mosteo 1 , Javier Glez-Vaz 2 , Belen Palencia 1 , Ignacio Melero 1 3 4 5 6
Abstract
CD137 (4-1BB) costimulation results in the potent activation of antitumor T lymphocytes and elicits antitumor efficacy that is synergistic with anti-PD(L)1 checkpoint inhibitors, especially when using bispecific constructs.
Emerging experimental evidence indicates that 4-1BB ligation prevents and may revert T-cell exhaustion. See related article by Jeon et al., p. 4155.
CITATION Clin Cancer Res. 2024 Sep 13;30(18):3971-3973. doi: 10.1158/1078-0432.CCR-24-1568
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