Agrypnia Excitata and Supranuclear Vertical Gaze Palsy Linked to Anti-Ma Encephalitis. Scientific Publication

Feb 18, 2024 | Magazine: Movement Disorders Clinical Practice

Christian Espinoza-Vinces 1 , Jaime Gállego Pérez-Larraya 1 , Ángel Ignacio Pérez-Álvarez 2 , Alejandro Horrillo-Maysonnial 3 , Marta Calvo-Imirizaldu 4 , Javier Arbizu 5 , Iciar Aviles-Olmos 1 , Elena Urrestarazu 3

Paraneoplastic neurological syndromes result from cancer's immune impact on the nervous system.1 Anti-Ma-associated encephalitis causes diencephalic, brainstem, and limbic symptoms such as memory loss, narcolepsy and rapid eye movement (REM) behavior disorder (RBD), eye movement abnormalities, and parkinsonism.2 It can precede cancer diagnosis, often linked to testicular tumors.3

Agrypnia excitata (AE) is a unique electroclinical syndrome that can disrupt sleep structure with changes in physiological cyclic organization, autonomic overactivity, and oneiric stupor episodes.4

We report on a patient with anti-Ma encephalitis who exhibits a diencephalic syndrome and AE, not previously reported to our knowledge.

CITATION Mov Disord Clin Pract. 2024 Feb 18. doi: 10.1002/mdc3.13997

see publication in pubmed