CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary. Scientific Publication

Dec 28, 2022 | Magazine: Cancer Discovery

Ignacio Melero 1 2 3 4 , Miguel F Sanmamed 1 2 3 4 , Javier Glez-Vaz 1 2 , Carlos Luri-Rey 1 2 , Jun Wang 5 , Lieping Chen 6

Abstract

CD137 (4-1BB) is a costimulatory receptor of T and natural killer lymphocytes whose activity can be exploited in cancer immunotherapy strategies as discovered 25 years ago.

Following initial attempts that met unacceptable toxicity, new waves of constructs acting agonistically on CD137 are being developed in patients, offering signs of clinical and pharmacodynamic activity with tolerable safety profiles.

CITATION Cancer Discov. 2023 Mar 1;13(3):552-569. doi: 10.1158/2159-8290.CD-22-1029

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Imagen del Dr. Ignacio Melero Bermejo, especialista en Inmunología de la Clínica Universidad de Navarra.

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Codirector Immunology and Immunotherapy Department

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Imagen del Dr. Miguel Fernández de Sanmamed Gutiérrez, Investigador principal del grupo Onco-Inmunología Aplicada y Traslacional de la Clínica Universidad de Navarra

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Specialist Medical Oncology Department

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