Immunothrombosis: A key mechanism in the COVID-19 pandemic

In the initial periods of SARS-CoV-2 (COVID-19) infection, the importance of thrombotic complications and the coexistence of hypercoagulability and hyperinflammation became evident, as they were responsible for macro and microvascular thrombotic manifestations identified in autopsies.

The thrombotic profile of COVID-19 patients was somewhat unusual, with a predominance of pulmonary microcirculation thrombosis rather than embolic etiology.

Additionally, the analytical data were also quite atypical, since, while extraordinarily elevated D-dimer values were observed, fibrinogen and platelet concentrations remained relatively normal, distinguishing it from conditions associated with infections that present with disseminated intravascular coagulation (DIC).

CITE THE ARTICLE Med Clin (Barc). 2024 Jul 30 (24)00403-2. doi: 10.1016/j.medcli.2024.05.027