Scientific publications
The role of C-reactive protein as a risk marker of postoperative delirium in older hip fracture patients: a prospective cohort study. Scientific Publication
Lucía Lozano-Vicario 1 , Ángel Javier Muñoz-Vázquez 2 , Bernardo Abel Cedeno-Veloz 3 , Román Romero-Ortuno 4 , Arkaitz Galbete 5 , Joaquín Fernández-Irigoyen 6 , Enrique Santamaría 6 , Fabricio Zambom-Ferraresi 5 7 , José Ramón Ortiz-Gómez 8 , Ángel Manuel Hidalgo-Ovejero 9 , Nicolás Martínez-Velilla 3 5 7
Purpose: Postoperative delirium (POD) is a common and serious neuropsychiatric syndrome that leads to higher morbidity and mortality. We investigated the association between serum C-reactive protein (CRP) and the occurrence of POD in older hip fracture patients, and whether CRP predicted POD better than a clinical model.
Methods: Patients aged ≥ 75 years admitted for surgical repair of an acute hip fracture were recruited. We compared serum CRP levels between patients with and without POD.
Results: Sixty patients were included, of whom 21 (35%) developed POD. Serum CRP levels were significantly higher in patients who developed delirium (p = 0.011). In a multiple regression model including clinical variables and CRP, cognitive impairment (p = 0.003) and infection (p = 0.001) were the best predictors of POD.
Conclusions: Although higher levels of serum CRP were significantly associated with POD in older hip fracture patients, pre-existing cognitive impairment and infections were the most important risk factors for POD.
CITATION Eur Geriatr Med. 2024 Sep 24. doi: 10.1007/s41999-024-01046-2
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