Scientific publications
Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome. Scientific Publication
Teresa Rognoni 1 , Marta Fernández-Matarrubia 2 , Miguel Ángel Martinez-González 3 4 5 6 , Jordi Salas-Salvadó 5 7 8 , Dolores Corella 5 9 , Olga Castañer 10 11 , J Alfredo Martínez 5 12 13 , Ángel M Alonso-Gómez 5 14 , Enrique Gómez-Gracia 15 , Jesús Vioque 11 16 , Dora Romaguera 5 17 , José López-Miranda 5 18 , Ramón Estruch 5 19 , Francisco J Tinahones 5 20 , José Manuel Santos-Lozano 5 21 , Lluis Serra-Majem 5 22 , Naomi Cano Ibañez 11 23 24 , Josep A Tur 5 25 , Rafael Micó Pérez 11 26 , Xavier Pintó 5 27 , Miguel Delgado-Rodríguez 11 28 , María Ortiz Ramos 29 , Josep Vidal 30 31 , Clotilde Vázquez 5 32 , Lidia Daimiel 5 13 33 , Emilio Ros 5 30 , Nuria Goñi-Ruiz 5 34 , Nancy Babio 5 7 8 , José V Sorlí 5 9 , Helmut Schröder 10 11 , Antonio García-Rios 5 18 , Laura Compañ-Gabucio 16 , Julia Warnberg 35 36 , M Ángeles Zulet 4 5 12 , Alice Chaplin 5 17 , Emilio Sacanella 5 19 , Amira Bouzalmate-Hajjaj 11 23 , Lucas Tojal-Sierra 5 14 , Miguel Damas-Fuentes 5 20 , Zenaida Vázquez 3 5 , Carlos Gómez-Martínez 5 7 8 , Carmen Saiz 5 9 , Mireia Malcampo 10 , Ana M Ortiz-Morales 5 18 , Vanessa Martínez-Avilés 37 , Jesús García-Gavilan 5 7 8 , Itziar Abete 4 5 12 , Montserrat Fitó 5 10 , Estefanía Toledo 3 4 5
Background: It has been proposed that physical activity (PA) could prevent cognitive decline.
Objective: To evaluate the association between changes in PA and changes in cognitive function in a cohort of adults with metabolic syndrome.
Methods: Longitudinal observational study including 5,500 adults (mean age 65 years, SD = 5; women = 49.3% ) with metabolic syndrome. Participants underwent physical activity measurements and cognitive evaluation at baseline and at two-years of follow-up. PA was quantified using the Minnesota questionnaire-shortened version. Cognitive function was evaluated using a battery of tests: Mini-Mental Test Examination, Clock Drawing Test, Trail Making Test A and B, Verbal Fluency Test, and Digit Span. The primary outcome was two-year change in cognition, measured through the Global Composite Score (GCS) of all neuropsychological tests. Multivariable-adjusted linear regression models were fitted with baseline PA and their changes as the main exposures and changes in cognitive function as the outcome.
Results: No significant association was found between PA levels (or their changes) in the GCS of cognitive function. A greater increase in PA levels was associated with a more favorable two-year change in the Trail Making Test A (Q4 versus Q1: b = - 2.24s, 95% CI -4.36 to -0.12s; p-trend = 0.020). No significant association was found for other neuropsychological test.
Conclusion: Our results do not support an association between increases in PA and the evolution of the global cognitive function at two-year in an intervention trial which included PA promotion in one of its two randomized arms, but they suggested a possible beneficial effect of PA on attentional function in older adults.
CITATION J Alzheimers Dis. 2023;95(3):887-899. doi: 10.3233/JAD-230105
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