Scientific publications
Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism. A cohort study. Scientific Publication
Marta Araujo-Castro 1 , Miguel Paja Fano 2 , Marga González-Boillos 3 , Eider Pascual-Corrales 1 , Paola Parra Ramírez 4 , Patricia Martín Rojas-Marcos 4 , Ana García-Cano 5 , Jorge Gabriel Ruiz-Sanchez 6 , Almudena Vicente 7 , Emilia Gómez-Hoyos 8 , Ana Casterás 9 , Albert Puig-Perez 9 , Iñigo García Sanz 10 , Mònica Recasens 11 , Rebeca Barahona San Millan 11 , María José Picón César 12 , Patricia Díaz Guardiola 13 , Carolina Perdomo 14 , Laura Manjón-Miguélez 15 , Ángel Rebollo Román 16 , Cristina Robles Lázaro 17 , José María Recio 17 , Manuel Morales-Ruiz 18 , María Calatayud 19 , Noemi Jiménez López 19 , Diego Meneses 6 , Miguel Sampedro Nuñez 20 , Elena Mena Ribas 21 , Alicia Sanmartín Sánchez 21 , Cesar Gonzalvo Diaz 22 , Cristina Lamas 22 , María Del Castillo Tous 23 , Joaquín Serrano 24 , Theodora Michalopoulou 25 , Susana Tenes Rodrigo 26 , Ricardo Roa Chamorro 27 , Fernando Jaén Aguila 27 , Eva María Moya Mateo 28 , Sonsoles Gutiérrez-Medina 29 , Felicia Alexandra Hanzu 30
Aim: To evaluate the influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism (PA).
Methods: Multicenter retrospective study of patients with PA in 36 Spanish tertiary hospitals with available information on smoking habits (smokers and non-smokers [never smokers and ex-smokers]).
Results: A total of 881 patients were included, of whom 180 (20.4%) were classified as smokers and 701 as non-smokers. At diagnosis, smokers and non-smokers did not differ in blood pressure or serum potassium levels between. However, smokers had a higher prevalence of left ventricular hypertrophy (LVH) than non-smokers (OR 2.0, 95% CI 1.23 to 3.25), and smokers were more likely to have severe LVH than non-smokers (12.5% vs. 6.6%, P=0.164). A larger mean tumor size of the adrenal nodule/s was observed in the smoking group (18.6±9.66 vs. 15.8±8.66 mm, P=0.002). In addition, the odds of mild autonomous cortisol secretion (MACS) was greater in smokers than in non-smokers (OR 2.1, 95% CI 1.14 to 4.06), but these differences disappeared when adjusted for the size of the adrenal nodule/s (adjusted OR 1.6, 95% CI 0.76 to 3.37). The rate of biochemical and hypertension cure was similar in both groups; however, hypertension cure tended to be more frequent in the non-smoker group (41.2% vs 29.9%, P=0.076).
Conclusions: Patients with PA who smoke have a higher prevalence of LVH and MACS and larger adrenal nodule/s than non-smokers. Smoking has no significant effect on the probability of hypertension response after adrenalectomy in patients with PA.
CITATION Eur J Endocrinol. 2024 Nov 18:lvae143. doi: 10.1093/ejendo/lvae143
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