Scientific publications
Prognostic markers of inflammation in endometrioid and clear cell ovarian cancer. Scientific Publication
Alejandro Gallego 1 , Marta Mendiola 2 3 , Barbara Hernando 4 , Alberto Berjon 2 5 , Alice Cadiz 4 , Blas Chaves-Urbano 4 , Victoria Heredia-Soto 6 , Emanuela Spagnolo 7 , Alicia Hernández Gutiérrez 7 8 , David Hardisson 2 3 5 8 , Geoff Macintyre 4 , Andres Redondo 9 10 , Maria Jose Garcia 11
Objectives: Cancer-related systemic inflammation has been associated with prognosis in multiple cancer types. Conversely, local inflammation, which is characterized by dense intratumoral immune infiltrates, is a favorable predictor of survival outcome. However, these survival associations are not well established in ovarian cancer, particularly in the less frequent endometrioid and clear cell endometriosis associated histotypes.
Methods: This retrospective study included 119 patients (63 endometrioid and 56 clear cell ovarian carcinomas). We performed a comprehensive survival association analysis of both systemic (neutrophil-to-lymphocyte ratio or presence of endometriosis) and local inflammation markers (CD3+ and CD8+ tumor infiltrating lymphocytes) using multivariate Cox proportional hazards models that account for confounding factors.
Results: Medium to high levels of intraepithelial CD8+ tumor infiltrating lymphocytes are associated with longer survival in endometrioid ovarian cancer (p=0.04). In addition, we found that intraepithelial CD8+ tumor infiltrating lymphocytes are prognostic in clear cell ovarian cancer (p=0.02), and that intraepithelial CD3+ tumor infiltrating lymphocytes are also associated with improved outcome (p=0.02). Furthermore, intratumoral CD3+ and CD8+ tumor infiltrating lymphocytes showed improved prognosis in the endometrioid subtype (p<0.1). No prognostic value was observed for systemic immune markers.
Conclusions: In this study, patients with endometrioid and clear cell ovarian cancer with moderate to high CD8+ and CD3+ intraepithelial tumor infiltrating lymphocytes had longer overall survival. Higher expression of intratumoral CD3+ and CD8+ tumor infiltrating lymphocytes also showed an improved outcome in endometrioid ovarian cancer. In contrast, systemic inflammation, evaluated by neutrophil-to-lymphocyte ratio or presence of endometriosis, did not have a prognostic impact in these histologic subtypes.
CITATION Int J Gynecol Cancer. 2022 Aug 1;32(8):1009-1016. doi: 10.1136/ijgc-2022-003353
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