Scientific publications
SENECA study: staging endometrial cancer based on molecular classification. Scientific Publication
Enrique Chacon 1 , Felix Boria 2 , R Rajagopalan Lyer 3 , Francesco Fanfani 4 , Mario Malzoni 5 , Petra Bretová 6 , Ana Luzarraga Aznar 7 , Robert Fruscio 8 9 , Marcin A Jedryka 10 11 , Richard Tóth 12 , Anna Myriam Perrone 13 , Athanasios Kakkos 14 , Ignacio Cristóbal Quevedo 15 , Luigi Congedo 16 17 , Vanna Zanagnolo 18 , Sergi Fernandez-Gonzalez 19 , Beatriz Ferro 20 , Fabrice Narducci 21 , Tatevik Hovhannisyan 22 , Elif Aksahin 23 , Laura Cardenas 24 , M Reyes Oliver 25 , Gonzalo Nozaleda 26 , Marta Arnaez 27 , Marcin Misiek 28 , Annamaria Ferrero 29 , Flore Anne Pain 30 , Janire Zarragoitia 31 , Cristina Diaz 32 , Lorenzo Ceppi 33 , Shamsi Mehdiyev 34 , Fernando Roldán-Rivas 35 36 , Alberto Rafael Guijarro-Campillo 37 , Joana Amengual 38 , Nabil Manzour 39 , Luisa Sanchez Lorenzo 40 , Jorge M Núñez-Córdoba 41 , Antonio Gonzalez Martin 40 , Jose Angel Minguez 42 , Luis Chiva 39 ; SENECA Working Group
Objective: Management of endometrial cancer is advancing, with accurate staging crucial for guiding treatment decisions. Understanding sentinel lymph node (SLN) involvement rates across molecular subgroups is essential. To evaluate SLN involvement in early-stage (International Federation of Gynecology and Obstetrics 2009 I-II) endometrial cancer, considering molecular subtypes and new European Society of Gynaecological Oncology (ESGO) risk classification.
Methods: The SENECA study retrospectively reviewed data from 2139 women with stage I-II endometrial cancer across 66 centers in 16 countries. Patients underwent surgery with SLN assessment following ESGO guidelines between January 2021 and December 2022. Molecular analysis was performed on pre-operative biopsies or hysterectomy specimens.
Results: Among the 2139 patients, the molecular subgroups were as follows: 272 (12.7%) p53 abnormal (p53abn, 1191 (55.7%) non-specific molecular profile (NSMP), 581 (27.2%) mismatch repair deficient (MMRd), 95 (4.4%) POLE mutated (POLE-mut). Tracer diffusion was detected in, at least one side, in 97.2% of the cases; with a bilateral diffusion observed in 82.7% of the cases. By ultrastaging (90.7% of the cases) or one-step nucleic acid amplification (198 (9.3%) of the cases), 205 patients were identified with affected sentinel lymph nodes, representing 9.6% of the sample. Of these, 139 (67.8%) had low-volume metastases (including micrometastases, 42.9%; and isolated tumor cells, 24.9%) while 66 (32.2%) had macrometastases. Significant differences in SLN involvement were observed between molecular subtypes, with p53abn and MMRd groups having the highest rates (12.50% and 12.40%, respectively) compared with NSMP (7.80%) and POLE-mut (6.30%), (p=0.004); (p53abn, OR=1.69 (95% CI 1.11 to 2.56), p=0.014; MMRd, OR=1.67 (95% CI 1.21 to 2.31), p=0.002). Differences were also noted among ESGO risk groups (2.84% for low-risk patients, 6.62% for intermediate-risk patients, 21.63% for high-intermediate risk patients, and 22.51% for high-risk patients; p<0.001).
Conclusions: Our study reveals significant differences in SLN involvement among patients with early-stage endometrial cancer based on molecular subtypes. This underscores the importance of considering molecular characteristics for accurate staging and optimal management decisions.
CITATION Int J Gynecol Cancer. 2024 Sep 2;34(9):1313-1321. doi: 10.1136/ijgc-2024-005711
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