Scientific publications
Uric Acid and acute kidney injury in high-risk patients for developing Acute Kidney Injury undergoing cardiac surgery: a prospective multicenter study
D Nagore 1 , A Candela 2 , M Bürge 3 , E Tamayo 4 , M Murie-Fernández 5 , M Vives 6 , P Monedero 7 , J Álvarez 8 , E Mendez 9 , A Pasqualetto 9 , T Mon 9 , R Pita 10 , M A Varela 10 , C Esteva 10 , M A Pereira 10 , J Sanchez 11 , M A Rodriguez 11 , A Garcia 12 , P Carmona 13 , M López 13 , A Pajares 13 , R Vicente 13 , R Aparicio 13 , I Gragera 14 , E Calderón 15 , J M Marcos 16 , L Gómez 17 , J M Rodríguez 18 , A Matilla 18 , A Medina 19 , A Hernández 20 , L Morales 21 , L Santana 21 , E Garcia 22 , S Montesinos 23 , P Muñoz 24 , B Bravo 25 , Julian Alvarez 26 , V Blanco 27 ; en nombre del Grupo Español de Investigación en Cirugía Cardiaca Perioperatoria
Purpose: It is unclear whether preoperative serum uric acid (SUA) elevation may play a role in the development of acute kidney injury (AKI) associated with cardiac surgery (CSA-AKI). We conducted a cohort study to evaluate the influence of preoperative hyperuricemia on AKI in patients at high risk for developing SC-AKI.
Design: Multicenter prospective international cohort study.
Setting: Fourteen university hospitals in Spain and the United Kingdom.
Participants: We studied 261 consecutive patients at high risk of developing CSA-AKI, according to a Cleveland score ≥4 points, from July to December 2017.
Interventions: None.
Measurements and main results: AKIN criteria were used for the definition of AKI. Multivariable logistic regression models and propensity score-matched pairwise analysis were used to determine the adjusted association between preoperative hyperuricemia (≥7 mg/dL) and AKI. Elevated preoperative AUS (≥7 mg/dL) was present in 190 patients (72.8%), whereas CSA-AKI occurred in 145 patients (55.5%). In multivariable logistic regression models, hyperuricemia was not associated with a significantly increased risk of AKI (adjusted Odds Ratio [OR]: 1.58; 95% confidence interval [CI]: 0.81-3; p = 0.17). In propensity score-matched analysis of 140 patients, the hyperuricemia group experienced similar adjusted odds of AKI (OR 1.05, 95%CI 0.93-1.19, p = 0.37).
Conclusions: Hyperuricemia was not associated with an increased risk of AKI in this cohort of patients undergoing cardiac surgery at high risk of developing CSA-AKI.
CITATION Rev Esp Anestesiol Reanim (Engl Ed). 2024 May 2:S2341-1929(24)00094-5. doi: 10.1016/j.redare.2024.04.019
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