Publicaciones científicas
Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study
Tijs J Hoogteijling 1 , Mohammad Abu Hilal 2 , Giuseppe Zimmitti 3 , Davit L Aghayan 4 , Andrew G R Wu 5 , Federica Cipriani 6 , Salvatore Gruttadauria 7 , Olivier Scatton 8 , Tran Cong Duy Long 9 , Paulo Herman 10 , Marco V Marino 11 , Vincenzo Mazzaferro 12 , Adrian K H Chiow 13 , Iswanto Sucandy 14 , Arpad Ivanecz 15 , Sung Hoon Choi 16 , Jae Hoon Lee 17 , Mikel Gastaca 18 , Marco Vivarelli 19 , Felice Giuliante 20 , Andrea Ruzzenente 21 , Chee Chien Yong 22 , Mengqiu Yin 23 , Constantino Fondevila 24 , Mikhail Efanov 25 , Zenichi Morise 26 , Fabrizio Di Benedetto 27 , Raffaele Brustia 28 , Raffaele Dalla Valle 29 , Ugo Boggi 30 , David Geller 31 , Andrea Belli 32 , Riccardo Memeo 33 , Alejandro Mejia 34 , James O Park 35 , Fernando Rotellar 36 , Gi Hong Choi 37 , Ricardo Robles-Campos 38 , Xiaoying Wang 39 , Robert P Sutcliffe 40 , Johann Pratschke 41 , Chung-Ngai Tang 42 , Charing C N Chong 43 , Mathieu D'Hondt 44 , Kazuteru Monden 45 , Santiago Lopez-Ben 46 , T Peter Kingham 47 , Alessandro Ferrero 48 , Giuseppe Maria Ettorre 49 , Daniel Cherqui 50 , Xiao Liang 51 , Olivier Soubrane 52 , Go Wakabayashi 53 , Roberto I Troisi 54 , Ho Seong Han 55 , Tan To Cheung 56 , Atsushi Sugioka 57 , Safi Dokmak 58 , Kuo Hsin Chen 59 , Rong Liu 60 , David Fuks 52 , Wanguang Zhang 61 , Luca Aldrighetti 6 , Bjørn Edwin 4 , Brian K P Goh 62 ; International robotic and laparoscopic liver resection study group investigators
Background: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood.
Methods: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed.
Results: 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy.
Conclusion: Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.
CITA DEL ARTÍCULO Eur J Surg Oncol. 2024 Apr 2;50(6):108309.
doi: 10.1016/j.ejso.2024.108309
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